Alleviative effects of <em>Bacillus coagulans</em>strains on IBS - Unraveling strain specificity through physiological and genomic analysis

The high intraspecies heterogeneity of B. coagulans leads to significant phenotypic differences among different strains. Thus, six coagulans strains were tested in the present study using an IBS animal model determine whether IBS-alleviating effects are strain-specific. results this showed that ingestion GBI-30, 6086, and CCFM1041 significantly alleviated symptoms mice. In contrast, other no or limited alleviating on symptoms. According our experimental results, two main common features these as follows: 1) resistance vegetative cells bile salts, 2) ability synthesize specific lipids secondary metabolites. Screening based indicators may greatly reduce costs provide a basis for mining new functional Our also suggest administration could regulate microbiota dysbiosis models. Moreover, close relationships between gut microbiota, metabolites, further confirmed study.